Males with female sexual companions of reproductive potential must not father a toddler and will use efficient contraception during therapy with VIDAZA.
Variety and percent of individuals who were being transfusion dependent at baseline who turned transfusion unbiased on treatment1
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Following administration in the suggested dosage for the first cycle, change dosage for subsequent cycles according to nadir counts and hematologic reaction [see DOSAGE AND ADMINISTRATION].
Hypomethylation may possibly restore standard purpose to genes which have been essential for differentiation and proliferation. The cytotoxic outcomes of azacitidine result in the Loss of life of swiftly dividing cells, which include most cancers cells that happen to be no longer aware of normal growth Command mechanisms. Non-proliferating cells are relatively insensitive to azacitidine.
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The suspension might be cloudy. The ensuing suspension will consist of azacitidine twenty five mg/mL. Don't filter the suspension following reconstitution. Doing so could eliminate the active material.
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The advised setting up dose for the first remedy cycle, for all patients in spite of baseline hematology laboratory values, is 75 mg/m² subcutaneously or intravenously, everyday for 7 days. Premedicate individuals for nausea and vomiting.
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